Bcs Class I
Bcs Class Iv Compound
Last Updated on Sun, 02 Dec 2018 The system is used to categorize drugs and serves to help anticipate whether drugs will have bioavailability/ bioequivalence problems. BCS classifies drugs according to their solubility and permeability. A drug is considered to have high solubility if drug substance at the highest dose strength for an immediate release formulation can be dissolved in 90%) or exhibits rapid movement through intestinal epithelia cells in vitro.
Bcs Class Iv
BCS classifies all drugs into four categories as shown in Table 3.3. Biopharmaceutics classification system BCS CLASS I High solubility High permeability BCS CLASS III High solubility Low permeability BCS CLASS II Low solubility High permeability BCS CLASS IV Low solubility Low permeability BCS class I compounds (high solubility and permeability) are unlikely to show bioavailability/bioequivalence issues. Therefore, for BCS class I drugs, in vitro dissolution studies are thought to provide sufficient information to assure in vivo product performance making full in vivo bioavailability/bioequivalence studies unnecessary.